Diabetes 2: antihyperglycemics

We reviewed the CDA 2013 guidelines on antihyperglycemic therapy for type 2 diabetes (http://guidelines.diabetes.ca/executivesummary/ch13), and explored the pharmacological properties of each of the major classes:

  • Biguanides: Metformin
  • Sulfonylureas: chlorpropamide, gliclazide, glimepiride, glyburide, and tolbutamide
  • Thiazolidinediones: pioglitazone and rosiglitazone
  • Meglitinides: Nateglinide and repaglinide
  • Alpha-glucosidase inhibitors: Acarbose
  • Dipeptidyl Peptidase-4 inhibitors (DPP4 inhibitors): Saxagliptin and sitagliptin
  • Glucagon Like Peptide-1 Analogues (GLP-1 analogues): Liraglutide and Exenatide

Drug information: