Category Archives: Atrial Fibrillation

A Fib 5: Antithrombotics

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Antiplatelets:

  • ASA
  • Clopidogrel

Anticoagulants:

  • Warfarin
  • Apixaban
  • Dabigatran
  • Rivaroxaban

Clotting Cascade:

File:Classical blood coagulation pathway.png

Clotting Factor Song, by Emily Anne Nagler:

Twelve, eleven, nine, it’s clotting factor time
8 and 9 to 10a 5, that’s how we stay alive

Don’t forget to say: the tissue factor way
7 to 7a helps 10 go to 10a

Then 2 to thrombin, and 1 to fibrin
And that’s how it ends

 

A Fib 4: Rhythm Control Medications

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Tina discusses the following rhythm control medications for atrial fibrillation:

Class 3 antiarrhythmics: blocks potassium channels and prolongs action potential duration

  • Amiodarone
  • Dronedarone
  • Sotalol

Class 1 antiarrhythmics: blocks sodium channels, which results in a slowed atrial conduction, lengthens atrial refractoriness, and suppresses automaticity

  • propafenone
  • flecainide

Indiana University’s P450 Drug Interaction Table: http://medicine.iupui.edu/clinpharm/ddis/clinical-table/

References:

A Fib 3: Rate Control Medications

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Tina discusses the following rate control medications for atrial fibrillation:

Beta blockers

  • Bisoprolol
  • Metoprolol
  • Atenolol

Calcium channel blockers (non-dihydropyridines)

  • verapamil
  • diltiazem

Digoxin

 

References: